Computational studies on the Carboni-Lindsey reaction
نویسندگان
چکیده
The Carboni-Lindsey reaction between tetrazines and strained unsaturated hydrocarbons has in recent years become a useful tool bioorthogonal chemistry for labelling biomolecules vitro vivo. Here, we report computational studies on the mechanism of Diels-Alder/Retro-Diels-Alder commercially available tetrazine norbornene. Isomerism with norbornene-amide relevant applications bioconjugation chemistry, as well role protonation mechanism, is assessed.
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ژورنال
عنوان ژورنال: Computational and Theoretical Chemistry
سال: 2021
ISSN: ['2210-2728', '2210-271X']
DOI: https://doi.org/10.1016/j.comptc.2021.113161